Many companies take measurements, but they are not publicly available. (9) in 2010 likewise demonstrated significantly elevated risks in petrochemical workers exposed to styrene when data for all categories of non-Hodgkin’s lymphoma are combined (Standardized Incidence Ratio = 1.87, 95% CI = 1.01–2.99, based on 15 cases) (10). 96-09-3. and their health effects. We've requested the relevant data in anonymised form from the companies that analyse the measurements , but unfortunately, we were unable to gain access to them," says Henrik Kolstad, "This is deeply regrettable, because the fact is that good answers to important questions presupposes that we also have access to the relevant information in the future.". The Factors That Do Increase Cancer Risk. We offer the following regional Styrene analysis and news coverage to keep you informed of factors and developments affecting prices in the Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene . We have therefore mapped the cancer incidence for those who worked in companies that used styrene in the production during the period 1968-2011," explains Henrik Kolstad on the background for what has ended up being the world's largest epidemiological study of styrene exposure in the reinforced plastics industry. The World Health Organization’s International Agency for Research on Cancer (IARC) has now upgraded the cancer-causing status of the common plastic ingredient styrene. This part of the study is published in Occupational and Environmental Medicine in the article 'Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry'. Styrene - ToxFAQs™ CAS # 100-42-5. For permissions, please e-mail: journals.permissions@oup.com. IARC in 2002, nearly 10 years ago, concluded that the evidence was already considerable but not fully sufficient for causality (5). Search for other works by this author on: Styrene. Philadelphia-negative myeloproliferative neoplasms among Kuwaiti Nationals. The authors (2) quote correctly that the ‘International Agency for Research on Cancer (IARC) classified styrene as possibly carcinogenic to humans (Group 2B) and SO as probably carcinogenic to humans (Group 2A)’. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. The predictive value of rodent carcinogenicity tests in the evaluation of human risks, Chemicals and cancer in humans: first evidence in experimental animals, Chemicals causally associated with cancers in humans and in laboratory animals: a perfect concordance, Lorenzo Tomatis and primary prevention of environmental cancer. Styrene is the precursor … Indeed, Boffetta et al. share. (2) recently reported cytogenetic and DNA damage in workers exposed to styrene and concluded their findings were supported by previous study results demonstrating genotoxicity associated with occupational exposure to styrene (e.g. "After 40 years in limbo: Styrene is probably carcinogenic." Among others before, Teixeira et al. We offer the following regional Styrene coverage to keep you informed of factors and developments affecting prices in the Europe Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene He faces a heightened risk of cancer because of his exposure to styrene, a chemical found in each of those products and in dozens of other consumer items, according to a U.S. government report. Both are genotoxic and form DNA adducts in humans. The NTP independent Board was not swayed or particularly impressed with the analysis and conclusions of the Boffetta et al. Four styrene-laden products to ditch. hide. "Possibly carcinogenic and should be investigated more closely." Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … The critical impact of tumor size in predicting cancer special survival for T3aM0M0 renal cell carcinoma: A proposal of an alternative T3aN0M0 stage. The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … Elevated incidence or mortality of lymphohematopoietic cancers was observed in large occupational cohorts of workers in the reinforced … report. It is not intended to provide medical or other professional advice. Styrene found in plastic products is linked with leukemia and nasal cancer risk, revealed research Aarhus University, Denmark. Another important research result is a fivefold risk for a particular type of nasal cancer following styrene exposure. Oxford University Press is a department of the University of Oxford. The European Union undertook a risk assessment of styrene and concluded that, “based on human studies, there is no clear and consistent evidence for a causal link between specific cancer mortality and exposure to styrene” (EU 2008, p. 271). For more information, call the ATSDR Information Center at 1-800-232-4636. "But in the instance of styrene… No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Background. Le styrène ne figurant pas sur la liste européenne des produits cancérogènes, il n’y a pas d’obligation d’appliquer le décret 2001-97 du 1er février 2001, dit décret CMR. There is sparse and inconsistent evidence of an association between styrene exposure and cancer. Chapter 1, The Case for Styrene… However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’. 12th Report on Carcinogens, National Toxicology Program, Cytogenetic and DNA damage on workers exposed to styrene, Styrene metabolism, genotoxicity, and potential carcinogenicity, Styrene Oxide CAS No. The 2006 US production of styrene was 11.4 million pounds (1), produced principally by catalytic dehydrogenation of ethylbenzene. New Device Detects Which Hand Gesture You Want to Make, Key Advance for Printing Circuitry on Wearable Fabrics, Luminescent Wood Could Light Up Homes of the Future, Research Lays Groundwork for Ultra-Thin, Energy Efficient Photodetector on Glass. Elevated risks of lymphohematopoietic cancer were found among workers with higher exposure to styrene after an appropriate elapsed time since first exposure. Manufactured styrene may contain aldehydes, which give it a sharp, unpleasant odor. The reason for different classifications from different organizations is partly a … This fact sheet is one in a series of summaries about hazardous substances . 19 Styrene ES Results for FRP Manufacturing (industrial) Risk Characterisation Manufacturing Activity RCR inhalation RCR dermal RCR all routes RMMs Open mold - rolling, brushing, etc. Styrene Modeling includes detailed, how-to modeling advice from more than a dozen accomplished craftsmen who have built every conceivable type of styrene model. In California this led to requirements for special product labelling, while EU countries do not have to label Roundup as a carcinogen. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. Exposure-related trend analyses also demonstrated increased risks (P < 0.05) for lymphomas in relation to increases in styrene exposures. (6) review on behalf of Styrene Information and Research Center, a styrene industry organisation, was presented by co-author P. Cole to the National Toxicology Program’s (NTP) Board of Scientific Counsellors open-to-the-public Peer Review of styrene (7). All rights reserved. 100% Upvoted. He is pleased with the fact that we in Denmark are able to do something that no other country can: "The reason for my presence in the working group is our register-based research, which is unique throughout the world, and where the most recent styrene study shows the risk of acute myeloid leukaemia, a rare form of leukemia, is doubled. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. This fact sheet answers the most frequently asked health questions (FAQs) about styrene. (styrene and [cancer or neoplasms] and [epidemiology or mortality or in-cidence]), without restriction of lan-guage or date of publication, as well as the references in the recent IARC Monograph1 and NTP Background Document.8 In a second PubMed search, we used the terms ([lymphoma or Hodgkin or Hodgkin’s or leukemia or … Roughly 99% of the industrial resins produced from styrene can be grouped into six major categories: polystyrene (50%), styrene-butadiene rubber (15%), unsaturated polyester resins (glass reinforced) (12%), styrene-butadiene latexes (11%), acrylonitrile-butadiene-styrene (10%) and styrene-acrylonitrile (1%) (1). "Clearly, the best place to study the possible health effects of styrene exposure is in the reinforced plasticsindustry, where no butadiene is involved. The reports are prepared by the International Agency for Research on Cancer (IARC), which is one of the WHO's expert bodies. Reasonably Anticipated to Be a Human Carcinogen. Methods. (6) styrene review paper ‘that no consistent increased risk of any cancer among workers exposed to styrene was found. One of the reasons why the results carry a lot of weight with the WHO is that Kolstad and his colleagues have been able to compare the research data from the cancer patients with measurements of styrene exposure in the Danish reinforced plastics industry over time. Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. James Huff, Peter F. Infante, Styrene exposure and risk of cancer, Mutagenesis, Volume 26, Issue 5, September 2011, Pages 583–584, https://doi.org/10.1093/mutage/ger033. save. En matière de prévention, il demeure important de savoir que le styrène est considéré comme «peut-être cancérogène pour l’homme» selon le Centre international de recherche contre le cancer. Is that only an issue if the tv gets smashed or something? Back-up Slides Styrene Exposure Scenarios . ScienceDaily shares links with sites in the. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. He is professor in occupational medicine, at the Department of Clinical Medicine at Aarhus University as well as Aarhus University Hospital. (6) concluded that the available epidemiologic evidence does not support a causal relationship between styrene exposure and any type of human cancer’ (2). These collective carcinogenicity findings clearly support, predated and predicted styrene carcinogenicity in humans (14–21), as nearly one-third of known human carcinogens were first identified in long-term bioassays (22–25). Hearing … Another example is the monograph that last year found that the herbicide glyphosate, better known as Roundup, can be carcinogenic. Government Agency reviews also concluded that styrene and its major metabolite styrene-7,8-oxide (SO) are both mutagenic and clastogenic as well as carcinogenic (1,4). Don't take our word for it, click on the linked chapters to have a look at some actual pages from the book in PDF format. But in a time when new studies on cancer links make news weekly, it’s easy to lose sight of the clear and consistent evidence: many common cancers have their roots in lifestyle factors. Hence, based on both animal and human cancer studies and genotoxic findings including clastogenicity and DNA damage in workers as well as on other supportive and biologically plausible mechanistic results, styrene and styrene-7,8-oxide should be considered as presenting carcinogenic risks to humans, particularly for lymphatic/hematopoietic cancers. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. Benchmark dose analysis of multiple genotoxicity endpoints in, Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients, The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals, Detection of urethane-induced genotoxicity. Conflict of interest statement: None declared. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … Other countries have done nothing. There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene … CAS No. There is also some evidence for increased risks of esophageal and pancreatic cancer among styrene-exposed workers. Subsequent epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumours. For forty years, this has been the conclusion of researchers who have been unsure of whether there is an increased risk of cancer associated with styrene. The conclusion that diets can play a role in lowering or increasing cancer … Styrene officially linked to cancer . 16 . Mette Skovgaard Christensen, Jesper Medom Vestergaard, Francesco d’Amore, Jette Sønderskov Gørløv, Gunnar Toft, Cecilia Høst Ramlau-Hansen, Zara Ann Stokholm, Inge Brosbøl Iversen, Mette Schou Nissen, Henrik Albert Kolstad. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. The mere fact that there’s a super-ominous warning about cancer and birth defects without any information regarding why it’s here, what materials of the product may cause cancer and in what way and if there are special handling pre-cautions that can be taken to avoid the danger makes me lose trust in the producer and assume the … "We've tried to make it clear that a listing in the report doesn't necessarily mean that encountering that substance in any minute quantity means you'll get cancer," said NTP Associate Director John Bucher. Styrene news and market information products from ICIS. 100-42-5. Styrene is included in synthetic rubber, some insulation materials, disposable tableware, packaging and fiberglass plastic. Styrene officially linked to cancer. The scientific effort to describe the potential for styrene exposure to cause cancer in humans may be entering its last phase. Was a member of the Boffetta et al in California this led to Germany the... 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